EMT-Related Genes Have No Prognostic Relevance in Metastatic Colorectal Cancer as Opposed to Stage II/III: Analysis of the Randomised, Phase III Trial FIRE-3 (AIO KRK 0306; FIRE-3)

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MCML Authors

Andreas Bender

Dr.

→ Group Bernd Bischl
Statistical Learning and Data Science

Shuo Chen

→ Group Volker Tresp
Database Systems, Data Mining and AI

Helmut Küchenhoff

Prof. Dr.

Principal Investigator

Statistical Consulting Unit (StaBLab)

Abstract

Despite huge advances in local and systemic therapies, the 5-year relative survival rate for patients with metastatic CRC is still low. To avoid over- or undertreatment, proper risk stratification with regard to treatment strategy is highly needed. As EMT (epithelial-mesenchymal transition) is a major step in metastatic spread, this study analysed the prognostic effect of EMT-related genes in stage IV colorectal cancer patients using the study cohort of the FIRE-3 trial, an open-label multi-centre randomised controlled phase III trial of stage IV colorectal cancer patients. Overall, the prognostic relevance of EMT-related genes seems stage-dependent. EMT-related genes have no prognostic relevance in stage IV CRC as opposed to stage II/III.

article

Cancers

14.22. Nov. 2022.

Authors

E. Pretzsch • V. Heinemann • S. Stintzing • A. Bender • S. Chen • J. W. Holch • F. O. Hofmann • H. Ren • F. Böschand • H. Küchenhoff • J. Werner • M. K. Angele