Redefining Spectral Unmixing for In-Vivo Brain Tissue Analysis From Hyperspectral Imaging
MCML Authors
Martin Menten
Dr.
JRG Leader AI for Vision
Daniel Rückert
Prof. Dr.
Director
Abstract
Martin Menten
Dr.
JRG Leader AI for Vision
Daniel Rückert
Prof. Dr.
Director
Abstract
In this paper, we propose a methodology for extracting molecular tumor biomarkers from hyperspectral imaging (HSI), an emerging technology for intraoperative tissue assessment. To achieve this, we employ spectral unmixing, allowing to decompose the spectral signals recorded by the HSI camera into their constituent molecular components. Traditional unmixing approaches are based on physical models that establish a relationship between tissue molecules and the recorded spectra. However, these methods commonly assume a linear relationship between the spectra and molecular content, which does not capture the whole complexity of light-matter interaction. To address this limitation, we introduce a novel unmixing procedure that allows to take into account non-linear optical effects while preserving the computational benefits of linear spectral unmixing. We validate our methodology on an in-vivo brain tissue HSI dataset and demonstrate that the extracted molecular information leads to superior classification performance.
inproceedings
CMMCA @MICCAI 2025
Workshop on Computational Mathematics Modeling in Cancer Analysis at 28th International Conference on Medical Image Computing and Computer Assisted Intervention. Daejeon, Republic of Korea, Sep 23-27, 2025.Authors
M. Hartenberger • H. Ayaz • F. Ozlugedik • C. Caredda • L. Giannoni • F. Lange • L. Lux • J. Weidner • A. Berger • F. Kofler • M. J. Menten • B. Montcel • I. Tachtsidis • D. Rückert • I. EzhovLinks
DOIResearch Area
BibTeXKey: HAO+25